LETAIRIS, the LETAIRIS logo, GILEAD, the GILEAD logo, and the More to My Story logo are registered trademarks of Gilead Sciences, Inc., or its related companies. All other marks referenced herein are the property of their respective owners.©2020 Gilead Sciences, Inc. All rights reserved. LETC0337 01/20 LETAIRIS, the LETAIRIS logo, GILEAD, the GILEAD logo, and the More to My Story logo are registered trademarks of Gilead Sciences, Inc., or its related companies. All other marks referenced herein are the property of their respective owners.©2020 Gilead Sciences, Inc. All rights reserved. LETC0337 01/20 If you are the parent or caregiver of a female child who started taking Letairis before reaching puberty, you should check your child regularly to see if she is developing signs of puberty. Tell your doctor right away if you notice that she is developing breast buds or any pubic hair. Your child may reach puberty before having her first menstrual period. Females can only receive Letairis through a restricted program called the Letairis Risk Evaluation and Mitigation (REMS) program. If you are a female who can get pregnant, you must talk to your doctor, understand the benefits and risks of Letairis, and agree to all of the instructions in the Letairis REMS program. The most common side effects of Letairis are swelling of hands, legs, ankles and feet (peripheral edema), stuffy nose (nasal congestion), inflamed nasal passages (sinusitis), hot flashes or getting red in the face (flushing). Tell your doctor if you have any side effect that bothers you or does not go away. The most common side effects of Letairis when taken with tadalafil are swelling of hands, legs, ankles and feet (peripheral edema), headache, stuffy nose (nasal congestion), cough, low red blood cell levels (anemia), indigestion (dyspepsia) or upper respiratory tract infection (bronchitis). Some medicines that are like Letairis can cause liver problems. Tell your doctor if you get any of these symptoms while taking Letairis: loss of appetite, nausea or vomiting, fever, achiness, generally do not feel well, pain in the upper right stomach (abdominal) area, yellowing of your skin or the whites of your eyes, dark urine, itching.